Fixation instability during binocular viewing in anisometropic and strabismic children. (June 2019)

• Record Type: Journal Article
• Authors: Kelly, Krista R.; Cheng-Patel, Christina S.; Jost, Reed M.; Wang, Yi-Zhong; Birch, Eileen E.
• Is Part Of: Experimental eye research. Volume 183(2019)
• Page Start: 29
• Page End: 37
• Publication Date: 2019-06
• Subjects: Fixation instability -- Vergence -- Amblyopia -- Strabismus -- Anisometropia -- Ocular motor development; Ophthalmology -- Periodicals; Eye -- Periodicals; Œil -- Périodiques; Ophthalmology; Periodicals; Electronic journals; 612.8405
• DOI: 10.1016/j.exer.2018.07.013
• Languages: English
• ISSNs: 0014-4835

Abstract

Abstract: Purpose: Strabismus or anisometropia disrupts binocularity and results in fixation instability, which is increased with amblyopia. Fixation instability has typically been assessed for each eye individually. Recently, vergence instability was reported in exotropic adults and monkeys during binocular viewing. We evaluated fixation instability during binocular viewing in children treated for anisometropia and/or strabismus. Methods: 160 children age 4–12 years with treated esotropia and/or anisometropia (98 amblyopic, 62 nonamblyopic) were compared to 46 age-similar controls. Fixation instability was recorded during binocular fixation of a 0.3 deg diameter dot for 20 s using a 500 Hz remote video binocular eye tracker (EyeLink 1000; SR Research). The bivariate contour ellipse area (BCEA; log deg 2 ) for fixation instability was calculated for each eye (nonpreferred, preferred) and for vergence instability (left eye position – right eye position). Best-corrected visual acuity, Randot Preschool stereoacuity, and extent of suppression scotoma (Worth 4-Dot) were also obtained. Results: When binocularly viewing, both amblyopic and nonamblyopic children treated for anisometropia and/or strabismus had larger fixation instability and vergence instability than controls. Amblyopia primarily added to the instability of the nonpreferred eye. Anisometropic children had less nonpreferred eye instability and vergence instability than those with strabismus or combined mechanism. Nonpreferred eye instability and vergence instability were related to poorer stereoacuity and a larger suppression scotoma. Preferred eye instability was not related to any visual outcome measure. No relationships were found with visual acuity. Conclusions: Fixation instability and vergence instability during binocular viewing suggests that discordant binocular visual experience during childhood, especially strabismus, interferes with ocular motor development. Amblyopia adds to instability of the nonpreferred eye. Vergence instability may limit potential for recovery of binocular vision in these children. Highlights: Fixation and vergence instability recorded during binocular viewing for 160 children with anisometropia, strabismus, or both and compared to 46 controls. Binocularly discordant visual experience, regardless of amblyopia, results in greater fixation and vergence instability than controls. Amblyopia adds to the instability of the nonpreferred eye. Children with strabismus had greater nonpreferred eye instability and vergence instability than children with anisometropia. Nonpreferred eye instability and vergence instability were associated with impaired binocular vision, not with nonpreferred eye visual acuity.