Correlational study on altered epicardial adipose tissue as a stratification risk factor for valve disease progression through IL-13 signaling. (July 2019)

• Record Type: Journal Article
• Authors: Vianello, Elena; Marrocco-Trischitta Massimiliano, Maria; Dozio, Elena; Bandera, Francesco; Tacchini, Lorenza; Canciani, Elena; Dellavia, Claudia; Schmitz, Gerd; Lorenzo, Menicanti; Corsi Romanelli Massimiliano, Marco
• Is Part Of: Journal of molecular and cellular cardiology. Volume 132(2019)
• Page Start: 210
• Page End: 218
• Publication Date: 2019-07
• Subjects: Valvular heart disease (VHD) -- Epicardial adipose tissue (EAT) -- IL-13 -- TGFβ1 -- Bone morphogenic proteins (BMPs) -- Wnt; Cardiology -- Periodicals; Heart Diseases -- Periodicals; Molecular Biology -- Periodicals; Cardiologie -- Périodiques; Cardiology; Electronic journals; Periodicals; 616.12
• DOI: 10.1016/j.yjmcc.2019.05.012
• Languages: English
• ISSNs: 0022-2828

Abstract

Abstract: Aims: Genetic and environmental factors all interact in the risk of progression of valvular dysfunctions. Previous studies reported a relation between valve diseases and epicardial adipose tissue (EAT) thickness. The aim of this study was to verify the possible relationship between the molecular pattern of EAT related to IL-13 fibrogenic cytokine expression and valve dysfunction. Methods and results: A valvular heart disease (VHD) population was stratified according to their median EAT thickness (7 mm). The molecular expression of IL-13 in EAT is directly related to the molecular expression of genes associated with extracellular matrix (ECM) turnover, macrophage infiltration and promotion of the formation of ectopic calcific nodules involved in aorta coarctation and calcification. Conclusion: IL-13 gene expression in altered EAT is directly related to the expression of genes involved in ECM turnover and the formation of ectopic calcific nodules, suggesting measurements of EAT as a stratification risk factor for valve instability in the VHD patients. Highlights: Congenital and non-congenital VHD correlated with pro-inflammatory markers associated with aorta stability. The amount of EAT correlated with aortic valve sclerosis. Altered EAT mass expresses fibrogenic IL-13 cytokines related to genes involved in tissue remodeling. IL-13 expressed by altered EAT directly correlated with genes related to valve stability and calcification.