Lebbeckoside C, a new triterpenoid saponin from the stem barks of Albizia lebbeck inhibits the growth of human glioblastoma cells. Issue 16 (18th August 2019)

• Record Type: Journal Article
• Authors: Noté, Olivier Placide; Ngo Mbing, Joséphine; Kilhoffer, Marie-Claude; Pegnyemb, Dieudonné Emmanuel; Lobstein, Annelise
• Is Part Of: Natural product research. Volume 33:Issue 16(2019)
• Page Start: 2292
• Page End: 2299
• Publication Date: 2019-08-18
• Subjects: Albizia lebbeck -- mimosaceae -- triterpenoid saponin -- cytotoxic activity -- U-87 MG and TG1 stem-like glioma cells; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1440231
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: One new acacic acid-type saponin, named lebbeckoside C (1 ), was isolated from the stem barks of Albizia lebbeck. Its structure was established on the basis of extensive analysis of 1D and 2D NMR ( 1 H, 13 C NMR, DEPT, COSY, TOCSY, ROESY, HSQC and HMBC) experiments, HRESIMS studies, and by chemical evidence as 3- O -[ β -d -xylopyranosyl-(l→2)- β -d -fucopyranosyl-(1→6)-[ β -d -glucopyranosyl(1→2)]- β -d -glucopyranosyl]-21- O -{(2 E, 6 S )-6- O -{4- O -[(2 E, 6 S )-2, 6-dimethyl-6- O -( β -d -quinovopyranosyl)octa-2, 7-dienoyl]-4- O -[(2 E, 6 S )-2, 6-dimethyl-6- O -( β -d -quinovopyranosyl)octa-2, 7-dienoyl]- β -d -quinovopyranosyl}-2, 6-dimethylocta-2, 7-dienoyl}acacic acid 28 O -[ β -d -quinovopyranosyl-(l→3)-[ α -l -arabinofuranosyl-(l→4)]- α -l -rhamnopyranosyl-(l→2)- β -d -glucopyranosyl] ester. The isolated saponin (1 ) displayed significant cytotoxic activity against the human glioblastoma cell line U-87 MG and TG1 stem-like glioma cells isolated from a patient tumor with IC50 values of 1.69 and 1.44 μM, respectively. Abstract :