Important roles of protein tyrosine phosphatase PTPN12 in tumor progression. (June 2019)

• Record Type: Journal Article
• Authors: Lee, Chaelin; Rhee, Inmoo
• Is Part Of: Pharmacological research. Volume 144(2019)
• Page Start: 73
• Page End: 78
• Publication Date: 2019-06
• Subjects: CD2BP1 CD2 binding protein 1 -- CDK2 Cyclin-dependent kinase 2 -- CID Chemistry in disks -- FOXO Forkhead box -- IKKβ IκB kinase β -- LFA-1 Lymphocyte function-associated antigen 1 -- LIM Lin11, Isl-1 & Mec-3 -- NPLH asparagine, proline, leucine and histidine -- PAK1 Serine/Threonine-protein kinase 1 -- PEST Proline-, Glutamate-, Serine-, Threonine- -- PSTPIP Proline-serine-threonine phosphatase-interacting protein -- PTK Protein Tyrosine Kinase -- PTP Protein Tyrosine Phosphatase -- PTPN12 Protein Tyrosine Phosphatase 12 -- PYCARD PYD And CARD Domain Containing -- SFK Src Family Kinase -- SH3 SRC Homology 3 -- SHP-1 Src homology region 2 domain-containing phosphatase-1 -- TCR T cell receptor -- TNBC Triple Negative Breast Cell -- WPD tryptophan, proline and aspartate; Chemical compounds studied in this article -- Dephostatin (CID: 2990) -- Sodium stibogluconate (CID: 16683013) -- Phenylarsine oxide (CID: 131726110) -- Vanadate (CID: 61672) -- Gallium nitrate (CID: 61635) -- Suramin (CID: 5361) -- Aplidin (CID: 9812534) -- MSI-1436 (CID: 9917968) -- SHP099 (CID: 118238298) -- RMC-4550 (CID: 134183206); Protein tyrosine phosphatases -- PTPN12/PTP-PEST -- Phosphorylation -- Breast cancer -- Signal transduction -- Inhibitors; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2019.04.011
• Languages: English
• ISSNs: 1043-6618

Abstract

Graphical abstract: Abstract: Protein tyrosine phosphatases (PTPs), which are ubiquitously expressed in hematopoietic and non-hematopoietic cells, are critical for regulating cell proliferation as well as differentiation in the physiology of multicellular organisms. PTPs regulate the intracellular signaling mechanism of immune cells via dephosphorylation of multiple targets and are associated with the onset of various autoimmune diseases through genomic alterations. PTPs also affect disease through their role in innate and/or acquired immunity. By modulating multiple substrates, PTPN12, a member of the proline-, glutamic acid-, serine- and threonine-rich (PEST) family of PTPs, is an important regulator of cell migration and adhesion. According to its newly identified roles and functions, PTPN12 is considered a promising therapeutic target against critical diseases, including cancer, diabetes, metabolic disease and autoimmune diseases. In this review, we provide an overview of PTPs and discuss the critical roles of PTPN12/PTP-PEST in tumor progression.