Oxysterol Binding Protein: Tether, Transporter… and Flux Capacitor?. Issue 7 (July 2019)

• Record Type: Journal Article
• Authors: Hammond, Gerald R.V.; Pacheco, Jonathan
• Is Part Of: Trends in cell biology. Volume 29:Issue 7(2019)
• Page Start: 531
• Page End: 533
• Publication Date: 2019-07
• Subjects: intrinsically disordered protein -- IDP -- low complexity sequence -- membrane contact site -- MCS -- OSBP-related protein -- ORP -- lipid transfer protein -- LTP; Cytology -- Periodicals; Cytology -- Research -- Periodicals; 571.6
• DOI: 10.1016/j.tcb.2019.04.004
• Languages: English
• ISSNs: 0962-8924

Abstract

Abstract : The oxysterol binding protein (OSBP) is a storied protein in organelle biology. Its early roles include acting as a membrane contact site (MCS) tether as well as a lipid antiporter. A surprising new function for OSBP in MCS dynamics has now been uncovered in a recent study by Jamecna et al. ( Dev. Cell 2019;49:220–234).