A self-assembled peptidic nanomillipede to fabricate a tuneable hybrid hydrogel. Issue 49 (3rd June 2019)

• Record Type: Journal Article
• Authors: Liu, Jianhui; Ni, Rong; Chau, Ying
• Is Part Of: Chemical communications. Volume 55:Issue 49(2019)
• Page Start: 7093
• Page End: 7096
• Publication Date: 2019-06-03
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc02967b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Peptidic 'nanomillipede', consisting of worm-like nanoscale 'body' and cysteine-terminated 'legs', was synthesized, tuned (with ultrasound) and utilized to crosslink the vinyl sulfone-modified dextran to form hybrid hydrogels with soft-tissue mimicking tuneable mechanical strength, self-healing property, and tuneable shear-thinning property, thereby indicating their potential use in tissue engineering and drug delivery. Abstract : A peptidic 'nanomillipede', consisting of a worm-like nanoscale 'body' and cysteine-terminated 'legs', was synthesized, tuned (with ultrasound) and utilized to crosslink the vinyl sulfone-modified dextran to form hybrid hydrogels with soft-tissue mimicking tuneable mechanical strength, self-healing property, and tuneable shear-thinning property, thereby indicating its potential use in tissue engineering and drug delivery.