Cascade intramolecular imidoylation and C–H activation/annulation of benzimidoyl chlorides with alkynes: one-pot synthesis of 7H-dibenzo[de, h]quinoline analogues. Issue 49 (3rd June 2019)

• Record Type: Journal Article
• Authors: Liu, Jiao; Fang, Hao; Cheng, Rui; Wang, Zhishuo; Yang, Yudong; You, Jingsong
• Is Part Of: Chemical communications. Volume 55:Issue 49(2019)
• Page Start: 7097
• Page End: 7100
• Publication Date: 2019-06-03
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc03400e
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Described herein is a cascade Lewis acid-promoted intramolecular Friedel–Crafts-type imidoylation and Rh(iii )-catalyzed C–H activation/annulation of benzimidoyl chlorides and alkynes, providing a divergent synthetic shortcut to 7 H -dibenzo[ de, h ]quinoline analogues. Abstract : Reported herein is a cascade Lewis acid-promoted intramolecular Friedel–Crafts-type imidoylation and Rh(iii )-catalyzed C–H activation/annulation of benzimidoyl chlorides and alkynes, providing a general and concise one-pot approach to 7 H -dibenzo[ de, h ]quinoline analogues. This divergent approach is based on a convergent retrosynthetic disconnection strategy.