Copper-catalyzed coupling of anthranils and α-keto acids: direct synthesis of α-ketoamides. Issue 24 (29th May 2019)

• Record Type: Journal Article
• Authors: Li, Ping-Gui; Zhu, Hao; Fan, Min; Yan, Cheng; Shi, Kai; Chi, Xi-Wen; Zou, Liang-Hua
• Is Part Of: Organic & biomolecular chemistry. Volume 17:Issue 24(2019)
• Page Start: 5902
• Page End: 5907
• Publication Date: 2019-05-29
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c9ob00822e
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Copper-catalyzed coupling of α-keto acids with anthranils is reported for the synthesis of α-ketoamides bearing an aldehyde group via N–O/C–O bond cleavages and C–N bond formation. Abstract : Copper-catalyzed coupling of α-keto acids with anthranils is reported for the synthesis of α-ketoamides. This process involves N–O/C–O bond cleavages and C–N bond formation. Furthermore, the decarboxylation of α-keto acids can be successfully suppressed under redox-neutral conditions.