Dual-channel fluorescent probe bearing two-photon activity for cell viability monitoring. Issue 23 (29th May 2019)

• Record Type: Journal Article
• Authors: Zhao, Yanqian; Zhang, Chengkai; Liu, Jiejie; Li, Dandan; Tian, Xiaohe; Wang, Aidong; Li, Shengli; Wu, Jieying; Tian, Yupeng
• Is Part Of: Journal of materials chemistry. Volume 7:Issue 23(2019)
• Page Start: 3633
• Page End: 3638
• Publication Date: 2019-05-29
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c9tb00512a
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : We developed a dual-channel two-photon fluorescence probe to monitor cell viability. Abstract : The search for a highly sensitive and efficient method to monitor cell viability is a high-priority yet challenging. In this study, two chromophores, 1OC and2OC, were rationally designed and fabricated to achieve excellent biocompatibility and two-photon activity in the near-infrared region. Fortunately, because of the introduction of water-soluble moieties and biocompatible triazole groups that link with the ether oxygen chain via a "Click" reaction, the obtained2OC displayed considerable biocompatibility and two-photon activity. Moreover, it revealed dual-channel fluorescence microscopy imaging for nucleolar and mitochondrial targeting, which can be employed for cell viability monitoring.