Biocompatibility Considerations in the Design of Graphene Biomedical Materials. Issue 11 (18th April 2019)

• Record Type: Journal Article
• Authors: Bullock, Christopher J.; Bussy, Cyrill
• Is Part Of: Advanced materials interfaces. Volume 6:Issue 11(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-04-18
• Subjects: biocompatibility -- graphene -- medical products -- safety testing; Materials science -- Periodicals; 620.11
• DOI: 10.1002/admi.201900229
• Languages: English
• ISSNs: 2196-7350

Abstract

Abstract: Graphene‐based materials (GBM) have outstanding properties that have proven highly beneficial in several proof‐of‐concept investigations on their biomedical potential. They can be used as suspensions of nanosheets for nanomedicine purposes as well as components of macroscale products in medical devices or tissue engineering/regenerative medicine products. However, the clinical translation of these preclinical concepts is hampered by the incomplete understanding of the biocompatibility of GBM in general, and the limited or lack of safety considerations in most preclinical proof‐of‐concept studies. In this review, the main safety aspects to be considered for the design of biocompatible materials based on GBM that interface with the human body or its fluids are outlined. Guidance to overcome some of the unique challenges presented by graphene biomedical materials are provided, stressing the need to consider safety challenges as early as possible in the design phase of the candidate biomedical product to raise its chance for clinical translation. Abstract : Graphene‐based materials (GBM) have outstanding properties that could be beneficial in several biomedical applications. However, the clinical translation of these materials is hampered by the incomplete understanding of their biocompatibility. Herein, the main safety aspects to be considered for the design of biocompatible materials based on GBM are provided, stressing the need to consider safety challenges as early as possible.