Assessing the Impact of Drug Resistance on the Transmission Dynamics of Typhoid Fever. (6th June 2013)

• Record Type: Journal Article
• Authors: Mushayabasa, S.; Bhunu, C. P.; Ngarakana-Gwasira, E. T.
• Other Names: Rehm Markus Academic Editor.
• Is Part Of: Computational biology journal. Volume 2013(2013)
• Publication Date: 2013-06-06
• Subjects: Computational biology -- Periodicals; Computational biology; Biología -- Publicaciones periódicas; Ciencias -- Publicaciones periódicas; Periodicals; Electronic journals; 570.285
• DOI: 10.1155/2013/303645
• Languages: English
• ISSNs: 2314-4165

Abstract

Abstract : Typhoid fever continues to be a major public health problem in the developing world. Antibiotic therapy has been the main stay of treating typhoid fever for decades. The emergence of drug-resistant typhoid strain in the last two decades has been a major problem in tackling this scourge. A mathematical model for investigating the impact of drug resistance on the transmission dynamics of typhoid fever is developed. The reproductive number for the model has been computed. Numerical results in this study suggest that when a typhoid outbreak occurs with more drug-sensitive cases than drug-resistant cases, then it may take 10–15 months for symptomatic drug-resistant cases to outnumber all typhoid cases, and it may take an average of 15–20 months for nonsymptomatic drug-resistant cases to outnumber all drug-sensitive cases.