Efficacy and Limitations of rCBF-SPECT in the Diagnosis of Alzheimer's Disease With Amyloid-PET. Issue 5 (August 2019)

• Record Type: Journal Article
• Authors: Takahashi, Miwako; Tada, Tomoko; Nakamura, Tomomi; Koyama, Keitaro; Momose, Toshimitsu
• Is Part Of: American journal of Alzheimer's disease & other dementias. Volume 34:Issue 5(2019)
• Page Start: 314
• Page End: 321
• Publication Date: 2019-08
• Subjects: regional cerebral blood flow SPECT -- amyloid-PET -- Alzheimer's disease -- mild cognitive impairment -- florbetapir-PET; Alzheimer's disease -- Periodicals; Dementia -- Periodicals; Alzheimer's disease -- Patients -- Care -- United States -- Periodicals; 616.83
• DOI: 10.1177/1533317519841192
• Languages: English
• ISSNs: 1533-3175

Abstract

This study aimed to assess efficacy and limitations of regional cerebral blood flow imaging using single-photon emission computed tomography (rCBF-SPECT) in the diagnosis of Alzheimer's disease (AD) with amyloid-positron emission tomography (amyloid-PET). Thirteen patients, who underwent both rCBF-SPECT and amyloid-PET after clinical diagnosis of AD or mild cognitive impairment, were retrospectively identified. The rCBF-SPECTs were classified into 4 grades, from typical AD pattern to no AD pattern of hypoperfusion; amyloid-beta (Aβ) positivity was assessed by amyloid-PET. Four patients were categorized into a typical AD pattern on rCBF-SPECT, and all were Aβ+. The other 9 patients did not exhibit a typical AD pattern; however, 4 were Aβ+. The Mini-Mental State Examination score and Clinical Dementia Rating scale were not significantly different between Aβ+ and Aβ– patients. A typical AD pattern on rCBF-SPECT can reflect Aβ+; however, if not, rCBF-SPECT has a limitation to predict amyloid pathology.