Preparation and In-vitro Degradation Behavior of Poly(L-lactide-co-glycolide-co-ε-caprolactone) Terpolymer. Issue 5 (4th May 2019)

• Record Type: Journal Article
• Authors: Wu, Wei; Zhou, Zhihua; Liu, Wenjuan; Zhao, Yunhui; Zhao, Yanmin; Huang, Tianlong; Li, Xiaofei; Fang, Jianjun
• Is Part Of: Journal of macromolecular science. Volume 58:Issue 5(2019)
• Page Start: 568
• Page End: 577
• Publication Date: 2019-05-04
• Subjects: L-lactide -- glycolide -- ε-caprolactone -- poly(L-lactide-co-glycolide-co-ε-caprolactone) -- degradation behavior; Polymerization -- Periodicals; Polymers -- Periodicals; 530.413
• DOI: 10.1080/00222348.2019.1601809
• Languages: English
• ISSNs: 0022-2348

Abstract

Abstract: A random terpolymer of poly(L-lactide-co-glycolide-co-ε-caprolactone) (PLLGC) was synthesized from L-lactide, glycolide and ε-caprolactone. The in-vitro hydrolytic degradation behavior of the PLLGC terpolymer was investigated as a function of the degradation time; the results showed that the degradation rate of PLLGC was lower than that of PLGA due to a reduction in the acidic degradation products. Therefore, we suggest the degradation rate of the PLGA could be controllable by introduction of ε-caprolactone into the PLGA martrix, while the physical properties (mechanical, etc.) were superior to PLGA.