Effect of nano‐sized SiO2 particles on the cognitive function and biochemical response. Issue 3 (4th May 2019)

• Record Type: Journal Article
• Authors: Salem, Amara; Oudhabechi, Amal; Sakly, Mohsen
• Is Part Of: Archives of environmental & occupational health. Volume 74:Issue 3(2019)
• Page Start: 140
• Page End: 146
• Publication Date: 2019-05-04
• Subjects: SiO2-NPs -- rat -- biochemical parameters -- memory -- toxicity -- histology; Medicine, Preventive -- Periodicals; Medicine, Industrial -- Periodicals; Environmental health -- Periodicals; Occupational diseases -- Periodicals; Environmental Health -- Periodicals; Occupational Medicine -- Periodicals; 616.9803
• DOI: 10.1080/19338244.2018.1489365
• Languages: English
• ISSNs: 1933-8244

Abstract

Abstract: Several in vitro studies have convincingly demonstrated that SiO2 NPs mediated cytotoxicity, which was dose-, time- and size-dependent. The data on in vivo toxicity of SiO2 NPs are even more contradictory. In the present study, we investigated the effects of sub-acute exposure to SiO2 -NPs on spatial learning and memory, the biochemical parameters and the histology of organs. Rats were injected intravenously with a single dose of SiO2 -NPs (20 mg/kg) during five consecutive days. The analysis of spatial memory in the Morris water maze showed that SiO2 -NPs disrupt the cognitive abilities of rats. Moreover, SiO2 -NPs could changes the blood counts. However, biochemical markers remained unchanged. Histological examination showed that SiO2 -NPs induced pathological changes in rat organs. In this finding NPs were shown to cause granuloma formation and inflammatory cells infiltration in the liver.