An Intraocular Inflammatory Profile of Rubella Associated Uveitis. (3rd April 2019)

• Record Type: Journal Article
• Authors: Fazil, Z.; Ten Berge, J. C.; Langerak, A. W.; Rothova, A.; Dik, W. A.
• Is Part Of: Ocular immunology and inflammation. Volume 27:Number 3(2019)
• Page Start: 418
• Page End: 423
• Publication Date: 2019-04-03
• Subjects: Cytokines -- Fuchs uveitis syndrome -- immunopathology -- rubella-virus associated uveitis -- intraocular fluid; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2017.1421671
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose : To analyze intraocular cytokine levels and cell profiles in patients with rubella virus-associated uveitis (RVU). Methods : We collected intraocular fluid samples from patients with RVU ( n = 10), uveitis of other causes ( n = 27), and cataract ( n = 22). Levels of 15 cytokines (IL-1β, IL-1ra, IL-2, IL-6, IL-6rα, IL-7, IL-8, IL-10, IL-17A, IL-23, TARC, MCP-1, TNF-α, PlGF, and VEGF) were measured using multiplex assay, and intraocular cell populations were determined by multiparameter flowcytometry. Clinical characteristics of RVU patients were collected and compared to laboratory outcomes. Results : RVU patients exhibited high intraocular levels of MCP-1, IL-6rα, and TARC, whilst patients with noninfectious uveitis were characterized by high levels of PlGF. Cataract patients showed high levels of IL-2 and IL-23. Intraocular cell population of RVU patients disclosed mainly T-cells and monocytes/macrophages and B-cells were scarcely detected. Conclusion : RVU patients exhibit a cytokine profile distinct from noninfectious uveitis and cataract.