Isochromanes from Aspergillus fumigatus, an endophytic fungus from Cordyceps sinensis. Issue 13 (3rd July 2019)

• Record Type: Journal Article
• Authors: Li, Xiao-Hua; Han, Xue-Hua; Qin, Ling-Ling; He, Jun-Lin; Cao, Zhi-Xing; Gu, Yu-Cheng; Guo, Da-Le; Deng, Yun
• Is Part Of: Natural product research. Volume 33:Issue 13(2019)
• Page Start: 1870
• Page End: 1875
• Publication Date: 2019-07-03
• Subjects: Aspergillus fumigatus -- azaphilone -- isochromane -- Cordyceps sinensis -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1478824
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Four previously undescribed isochromanes were isolated from the fermentation broth of an endophytic fungus Aspergillus fumigatus, which was obtained from the fruiting body of Cordyceps sinensis . Their structures were elucidated through extensive spectroscopic analyses. One racemic isochromane was further purified by chiral HPLC to yield a pair of enantiomers and their absolute configurations were determined by quantum chemical ECD calculations. These isolated compounds were evaluated for cytotoxicity against two cell lines (MV4-11 and MDA-ME-231) and the result showed that compounds1a and2 exhibited moderate growth inhibition against MV4-11 cell line. Abstract :