Two new echinocystic acid derivatives catalyzed by filamentous fungus Gliocladium roseum CGMCC 3.3657. Issue 13 (3rd July 2019)

• Record Type: Journal Article
• Authors: Fu, Shao-Bin; Feng, Xu; Meng, Qing-Feng; Cai, Qing; Sun, Di-An
• Is Part Of: Natural product research. Volume 33:Issue 13(2019)
• Page Start: 1842
• Page End: 1848
• Publication Date: 2019-07-03
• Subjects: Echinocystic acid -- biotransformation -- structure modification -- Gliocladium roseum CGMCC 3.3657 -- pentacyclictriterpene; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1477148
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Biotransformation of Echinocystic acid (EA, 1 ) using G. roseum CGMCC 3.3657 has been investigated, which leads to the isolation and identification of two novel Echinocystic acid derivatives, 4, 16α-dihydroxy-3, 4-seco-olean-12-en-3, 28-dioic acid (2 ) and 16α-hydroxy, A-homo-3α-oxa-olean-12-en-3-one-28-oic acid (3 ). Their structures have been elucidated by analysis of spectroscopic data. This biocatalysis could serve as an efficient tool complementary to classical chemical methods for the transformation of EA. Abstract :