Fluorescent probe for Cu2+ and the secondary application of the resultant complex to detect cysteine. Issue 29 (29th May 2019)

• Record Type: Journal Article
• Authors: Yang, Meipan; Ma, Lifeng; Li, Jing; Kang, Longli
• Is Part Of: RSC advances. Volume 9:Issue 29(2019)
• Page Start: 16812
• Page End: 16818
• Publication Date: 2019-05-29
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9ra02360g
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A special fluorescent probe has been developed with high selectivity toward Cu 2+ in living cells and mice, and the probe–Cu 2+ complex could detect cysteine without obvious interference. Abstract : A special fluorescent probe has been developed, one that demonstrated excellent "off-on-type" change in fluorescence with high selectivity toward Cu 2+ . Interestingly, the probe–Cu 2+ complex could detect cysteine due to the ability of this amino acid to strongly coordinate Cu 2+, and no obvious interference was observed from other amino acids and anions. According to the proposed mechanism, addition of cysteine induced decomplexation of the probe–Cu 2+ form. Furthermore, the results of confocal microscopy experiments demonstrated the potential of using the probe to image Cu 2+ in living cells and mice.