Recent advances in reaction-based fluorescent probes for detecting monoamine oxidases in living systems. Issue 12 (7th May 2019)

• Record Type: Journal Article
• Authors: Huang, Jintao; Hong, Danqi; Lang, Wenjie; Liu, Jian; Dong, Jia; Yuan, Chaonan; Luo, Jie; Ge, Jingyan; Zhu, Qing
• Is Part Of: Analyst. Volume 144:Issue 12(2019)
• Page Start: 3703
• Page End: 3709
• Publication Date: 2019-05-07
• Subjects: Chemistry, Analytic -- Periodicals; 543
• DOI: 10.1039/c9an00409b
• Languages: English
• ISSNs: 0003-2654

Abstract

Abstract : This Minireview summarizes the recent advances in reaction based MAO type fluorescent probes and their imaging applications in living systems. Abstract : Monoamine oxidase (MAO) is a membrane-bound mitochondrial enzyme that plays an important role by catalyzing oxidative deamination to maintain the homeostasis of neurotransmitters and other biogenic amines in living systems. MAO activity is critical for the brain and central nervous system. Its dysfunction is closely related with many neurological and psychiatric disorders. Fluorescent probes provide a useful approach to accurately detect MAO activity and assist to better elucidate their biological functions. Herein, in this Minireview, we summarize the recent advances in reaction based MAO type fluorescent probes and their imaging applications in living systems.