Gene-Drug Interaction in Stroke. (10th November 2011)

• Record Type: Journal Article
• Authors: Amici, Serena; Paciaroni, Maurizio; Agnelli, Giancarlo; Caso, Valeria
• Other Names: Debette Stephanie Academic Editor.
• Is Part Of: Stroke research and treatment. Volume 2011(2011)
• Publication Date: 2011-11-10
• Subjects: Cerebrovascular disease -- Periodicals; Stroke; Cerebrovascular Disorders; Cerebrovascular disease; Periodicals; Periodicals; Fulltext; Internet Resources; Periodicals; 616.81
• DOI: 10.4061/2011/212485
• Languages: English
• ISSNs: 2090-8105

Abstract

Abstract : Stroke is the third cause of mortality and one of most frequent causes of long-term neurological disability, as well as a complex disease that results from the interaction of environmental and genetic factors. The focus on genetics has produced a large number of studies with the objective of revealing the genetic basis of cerebrovascular diseases. Furthermore, pharmacogenetic research has investigated the relation between genetic variability and drug effectiveness/toxicity. This review will examine the implications of pharmacogenetics of stroke; data on antihypertensives, statins, antiplatelets, anticoagulants, and recombinant tissue plasminogen activator will be illustrated. Several polymorphisms have been studied and some have been associated with positive drug-gene interaction on stroke, but the superiority of the genotype-guided approach over the clinical approach has not been proved yet; for this reason, it is not routinely recommended.