Angiosarcoma Arising in an Ovarian Fibroma: A Case Report. (17th October 2010)

• Record Type: Journal Article
• Authors: Cambruzzi, Eduardo; Pegas, Karla Lais; Milani, Daniel Marini; Cruz, Ricardo Pedrini; Guerra, Enilde Heloena; Ferrari, Márcio Balbinotti
• Other Names: Van Diest P. J. Academic Editor.
• Is Part Of: Pathology research international. Volume 2010(2010)
• Publication Date: 2010-10-17
• Subjects: Pathology -- Periodicals; 571.905
• DOI: 10.4061/2010/842592
• Languages: English
• ISSNs: 2090-8091

Abstract

Abstract : Primary ovarian angiosarcoma is a very rare gynaecological sarcoma, with poor prognosis. These tumors are though to arise from carcinosarcomas, teratomas, or the ovarian vasculature and occur at any age. There are only a few cases reported in the international literature, most commonly associated to surface epithelial-stromal or germ cell tumours. Herein, the authors report the clinicopathologic features of an angiosarcoma arising in an ovarian fibroma. A 65-year-old patient was admitted with a palpable mass in the hypogastrium. Grossly, the removed ovary was completely replaced by a solid tumor mass. On histological analysis, the lesion revealed the typical histological features of angiosarcoma with sinusoidal patterns and anaplastic cells, admixed with spindle-shaped cells arranged in fascicles or in a storiform pattern, compatible with a fibroma. The vascular component was strongly immunopositive for CD31 and CD34. The patient was submitted to chemotherapy, and she was alive for two months after surgical proceedings.