Synthesis, Characterization, and Biological Activity of 5-Phenyl-1, 3, 4-thiadiazole-2-amine Incorporated Azo Dye Derivatives. (18th August 2013)

• Record Type: Journal Article
• Authors: Keerthi Kumar, Chinnagiri T.; Keshavayya, Jathi; Rajesh, Tantry N.; Peethambar, Sanehalli K.; Shoukat Ali, Angadi R.
• Other Names: Aly Shehata Ashraf Academic Editor.
• Is Part Of: Organic chemistry international. Volume 2013(2013)
• Publication Date: 2013-08-18
• Subjects: Chemistry, Organic -- Periodicals; Chemistry, Organic; Periodicals; 547
• DOI: 10.1155/2013/370626
• Languages: English
• ISSNs: 2090-200X

Abstract

Abstract : 5-Phenyl-1, 3, 4-thiadiazole-2-amine has been synthesized by single step reaction. A series of heterocyclic azodyes were synthesized by diazotisation of 5-phenyl-1, 3, 4-thiadiazole-2-amine by nitrosyl sulphuric acid followed by coupling with different coupling compounds such as 8-hydroxyquinoline, 2, 6-diaminopyridine, 2-naphthol, N, N-dimethyl aniline, resorcinol, and 4, 6-dihydroxypyrimidine. The dyes were characterized by UV-Vis, IR, 1 H-NMR, 13 C NMR, and elemental analysis. The synthesized compounds were also screened for biological activity.