Biology of the KCNQ1 Potassium Channel. (29th January 2014)

• Record Type: Journal Article
• Authors: Abbott, Geoffrey W.
• Other Names: Combaret Lydie Academic Editor.
• Is Part Of: New journal of science. Volume 2014(2014)
• Publication Date: 2014-01-29
• Subjects: Life sciences -- Periodicals; Life sciences; Electronic journals; Periodicals; 500
• DOI: 10.1155/2014/237431
• Languages: English
• ISSNs: 2356-7740

Abstract

Abstract : Ion channels are essential for basic cellular function and for processes including sensory perception and intercellular communication in multicellular organisms. Voltage-gated potassium (Kv) channels facilitate dynamic cellular repolarization during an action potential, opening in response to membrane depolarization to facilitate K + efflux. In both excitable and nonexcitable cells other, constitutively active, K + channels provide a relatively constant repolarizing force to control membrane potential, ion homeostasis, and secretory processes. Of the forty known human Kv channel pore-forming α subunits that coassemble in various combinations to form the fundamental tetrameric channel pore and voltage sensor module, KCNQ1 is unique. KCNQ1 stands alone in having the capacity to form either channels that are voltage-dependent and require membrane depolarization for activation, or constitutively active channels. In mammals, KCNQ1 regulates processes including gastric acid secretion, thyroid hormone biosynthesis, salt and glucose homeostasis, and cell volume and in some species is required for rhythmic beating of the heart. In this review, the author discusses the unique functional properties, regulation, cell biology, diverse physiological roles, and involvement in human disease states of this chameleonic K + channel.