Analysis of Expression of Vascular Endothelial Growth Factor A and Hypoxia Inducible Factor-1alpha in Patients Operated on Stage I Non-Small-Cell Lung Cancer. (10th February 2014)

• Record Type: Journal Article
• Authors: Honguero Martínez, Antonio Francisco; Arnau Obrer, Antonio; Figueroa Almánzar, Santiago; León Atance, Pablo; Guijarro Jorge, Ricardo
• Other Names: Iyoda Akira Academic Editor.
• Is Part Of: Lung cancer international. Volume 2014(2014)
• Publication Date: 2014-02-10
• Subjects: Lungs -- Cancer -- Periodicals; Lung Neoplasms; Lungs -- Cancer; Periodical; Periodicals; Fulltext; Internet Resources; Periodicals; Electronic journals; 616.99424
• DOI: 10.1155/2014/810786
• Languages: English
• ISSNs: 2090-3197

Abstract

Abstract : Objectives . Recent studies show that expression of hypoxia inducible factor-1alpha (HIF-1 α ) favours expression of vascular endothelial growth factor A (VEGF-A), and these biomarkers are linked to cellular proliferation, angiogenesis, and metastasis in different cancers. We analyze expression of HIF-1 α and VEGF-A to clinicopathologic features and survival of patients operated on stage I non-small-cell lung cancer. Methodology . Prospective study of 52 patients operated on with stage I. Expression of VEGF-A and HIF-1 α was performed through real-time quantitative polymerase chain reaction (qRT-PCR). Results . Mean age was 64.7 and 86.5% of patients were male. Stage IA represented 23.1% and stage IB 76.9%. Histology classification was 42.3% adenocarcinoma, 34.6% squamous cell carcinoma, and 23.1% others. Median survival was 81.0 months and 5-year survival 67.2%. There was correlation between HIF-1 α and VEGF-A (P = 0.016 ). Patients with overexpression of HIF-1 α had a tendency to better survival with marginal statistical significance (P = 0.062 ). Patients with overexpression of VEGF-A had worse survival, but not statistically significant (P = 0.133 ). Conclusion . The present study revealed that VEGF-A showed correlation with HIF-1 α . HIF-1 α had a tendency to protective effect with aP value close to statistical significance. VEGF-A showed a contrary effect but without statistical significance.