Thymidylate Synthase as a Predictive Biomarker for Pemetrexed Response in NSCLC. (25th December 2013)

• Record Type: Journal Article
• Authors: Bukhari, Ali A.; Goudar, Ranjit K.
• Other Names: Leighl Natasha B. Academic Editor.
• Is Part Of: Lung cancer international. Volume 2013(2013)
• Publication Date: 2013-12-25
• Subjects: Lungs -- Cancer -- Periodicals; Lung Neoplasms; Lungs -- Cancer; Periodical; Periodicals; Fulltext; Internet Resources; Periodicals; Electronic journals; 616.99424
• DOI: 10.1155/2013/436409
• Languages: English
• ISSNs: 2090-3197

Abstract

Abstract : In recent years, major strides in cancer research have made it possible to select personalized chemotherapy recommendations based on an individual patient's tumor biology. The prognostic and/or predictive ability of biomarkers seeks to tailor the use of targeted chemotherapy and can result in improved clinical outcomes with reduced toxicity. A proliferation of new technology and pharmacotherapeutics in the setting of current FDA Clinical Laboratory Improvement Amendment (CLIA) standards has resulted in a recent surge in direct-to-physician biomarker tests. However, in the absence of clinical validation, there is the concern that the biomarkers may be utilized prematurely, resulting in improper chemotherapy selection and patient harm. Thymidylate synthase (TS) has been marketed as a predictive biomarker for the use of pemetrexed in NSCLC. We will examine the evidence behind the use of TS as a predictive biomarker to predict response to pemetrexed in NSCLC. At this time, the evidence does not currently support using TS assays to guide chemotherapy selection outside of a clinical research protocol.