Antiamnesic Effects of a Hydroethanolic Extract of Crinum macowanii on Scopolamine-Induced Memory Impairment in Mice. (8th October 2015)

• Record Type: Journal Article
• Authors: Mugwagwa, Andrew T.; Gadaga, Louis L.; Pote, William; Tagwireyi, Dexter
• Other Names: Simola Nicola Academic Editor.
• Is Part Of: Journal of neurodegenerative diseases. Volume 2015(2015)
• Publication Date: 2015-10-08
• Subjects: Nervous system -- Degeneration -- Periodicals; Neurodegenerative Diseases; Nervous system -- Degeneration; Periodicals; 616.8
• DOI: 10.1155/2015/242505
• Languages: English
• ISSNs: 2090-858X

Abstract

Abstract : Crinum macowanii has been found to contain alkaloids that have activity against acetylcholinesterase enzyme in vitro . The present study was undertaken to investigate the in vivo ability of hydroethanolic crude extract of Crinum macowanii to ameliorate memory impairment induced by scopolamine. Thirty-six male Balb/c mice weighing around 25–35 g were employed in the present investigation. Y-maze and novel object recognition apparatus served as the exteroceptive behavioural models, and scopolamine-induced amnesia served as the interoceptive behavioural model. C. macowanii (10, 20, and 40 mg/kg p.o.) was administered in single doses to the mice. Donepezil (3 mg/kg p.o.) was used as a positive control agent. C. macowanii extract reversed the amnesia induced by scopolamine as indicated by a dose-dependent increase in spontaneous alternation performance in the Y-maze task. C. macowanii 40 mg/kg showed significant activity (p < 0.05 versus negative control), comparable to that of the positive control. C. macowanii also showed memory-enhancing activity against scopolamine-induced memory deficits in the long-term memory novel object recognition performance as indicated by a dose-dependent increase in the discrimination index. The results indicate that the hydroethanolic extract of C. macowanii may be a useful memory restorative mediator in the treatment of cognitive disorders such as Alzheimer's disease.