Crystal Structure of Apraclonidine Hydrochloride. (21st October 2013)

• Record Type: Journal Article
• Authors: Hirayama, Noriaki
• Other Names: Akkurt Mehmet Academic Editor.; Gomes Lígia R. Academic Editor.; Lowe Edward D. Academic Editor.; Matias Pedro M. Academic Editor.
• Is Part Of: Journal of crystallography. Volume 2013(2013)
• Publication Date: 2013-10-21
• Subjects: Crystallography -- Periodicals; Crystallography; Periodicals; 548
• DOI: 10.1155/2013/249672
• Languages: English
• ISSNs: 2356-7317

Abstract

Abstract : Apraclonidine is used for the treatment of postsurgical elevated intraocular pressure. The crystal structure of its hydrochloride, C9 H10 Cl2 N4 · HCl, was determined by X-ray analysis. The crystal belongs to space groupP 2 1 / n with the cell dimensionsa = 9.665 ( 10 ), b = 11.8624 ( 14 ), c = 10.5675 ( 11 ) Å, andβ = 92.199 ( 9 ) °. The finalR (all reflections) value is 0.053. Apraclonidine has a more twisted structure than its related drug of clonidine. The nitrogen atom bridging the two rings is protonated.