On the Role of Optimal Counseling and Antiviral Therapy on Controlling HCV among Intravenous Drug Misusers. (25th June 2014)

• Record Type: Journal Article
• Authors: Mushayabasa, Steady
• Other Names: Ng Hon Keung Tony Academic Editor.
• Is Part Of: Journal of computational medicine. Volume 2014(2014)
• Publication Date: 2014-06-25
• Subjects: Medical informatics -- Periodicals; Computational intelligence -- Periodicals; Computational intelligence; Medical informatics; Periodicals; Electronic journals; 610.285
• DOI: 10.1155/2014/347827
• Languages: English
• ISSNs: 2314-5080

Abstract

Abstract : Hepatitis C virus (HCV) remains a major health challenge despite the availability of highly effective antiviral drugs. Prior studies suggest that many physicians are reluctant to treat intravenous drug misusers due to low levels of treatment adherence associated with intravenous drug misusers. HCV treatment guidelines and recommendations stipulate that HCV patients in treatment should abstain from intravenous drug misuse activities in order to reduce the likelihood of treatment failure, drug resistance, reinfection, superinfection, or mixed infection. In this paper, a mathematical model for exploring the transmission dynamics of HCV among intravenous drug misusers is proposed. The model incorporates essential characteristics of intravenous drug misusers such as relapse and nonadherence to treatment guidelines. With the aid of optimal control theory we assess the effects of time dependent HCV screening and treatment. Results from this study provide a framework for designing the appropriate strategies on controlling the long-term dynamics of HCV among intravenous drug users.