Reduced Dynamic Models in Epithelial Transport. (28th February 2013)

• Record Type: Journal Article
• Authors: Hernández, Julio A.
• Other Names: Herrmann Andreas Academic Editor.
• Is Part Of: Journal of biophysics. Volume 2013(2013)
• Publication Date: 2013-02-28
• Subjects: Biophysics -- Periodicals; Biophysics; Biophysical Phenomena; Biophysics; Periodical; Periodicals; Electronic journals; Fulltext; Internet Resources; Periodicals; 571.4
• DOI: 10.1155/2013/654543
• Languages: English
• ISSNs: 1687-8000

Abstract

Abstract : Most models developed to represent transport across epithelia assume that the cell interior constitutes a homogeneous compartment, characterized by a single concentration value of the transported species. This conception differs significantly from the current view, in which the cellular compartment is regarded as a highly crowded media of marked structural heterogeneity. Can the finding of relatively simple dynamic properties of transport processes in epithelia be compatible with this complex structural conception of the cell interior? The purpose of this work is to contribute with one simple theoretical approach to answer this question. For this, the techniques of model reduction are utilized to obtain a two-state reduced model from more complex linear models of transcellular transport with a larger number of intermediate states. In these complex models, each state corresponds to the solute concentration in an intermediate intracellular compartment. In addition, the numerical studies reveal that it is possible to approximate a general two-state model under conditions where strict reduction of the complex models cannot be performed. These results contribute with arguments to reconcile the current conception of the cell interior as a highly complex medium with the finding of relatively simple dynamic properties of transport across epithelial cells.