Effect of Indoxyl Sulfate on Oxidative Stress, Apoptosis, and Monocyte Chemoattractant Protein-1 in Leukocytes. (14th April 2014)

• Record Type: Journal Article
• Authors: Cruz, Edgar Ferreira da; Cendoroglo, Miguel; Manfredi, Silvia Regina; Eugênia Canziani, Maria; Quinto, Beata Marie Redublo; Grabulosa, Caren Cristina; Guimarães-Souza, Nadia Karina; Peres, Aline Trevisan; Carvalho, José Tarcísio Giffoni de; Batista, Marcelo Costa; Dalboni, Maria Aparecida
• Other Names: Ercal N. Academic Editor.; Liu J. Academic Editor.
• Is Part Of: ISRN oxidative medicine. Volume 2014(2014)
• Publication Date: 2014-04-14
• Subjects: Medicine -- Periodicals; Electronic journals; Periodicals; 610
• DOI: 10.1155/2014/412389
• Languages: English
• ISSNs: 2314-6400

Abstract

Abstract : This study showed that indoxyl sulfate, an uremic toxin present in the serum of patients with chronic kidney disease, increases oxidative stress and apoptosis in human neutrophils and reduces the production of monocyte chemoattractant protein-1 (MCP-1) by peripheral blood mononuclear cell (PBMC). It is possible that these effects caused by this toxin contribute to vascular injury of the endothelium and decreased response to infectious insults, respectively.