Heart-Kidney Biomarkers in Patients Undergoing Cardiac Stress Testing. (30th September 2010)

• Record Type: Journal Article
• Authors: Haapio, Mikko; House, Andrew A.; de Cal, Massimo; Cruz, Dinna N.; Lentini, Paolo; Giavarina, Davide; Fortunato, Antonio; Menghetti, Luigi; Salgarello, Matteo; Lupi, Andrea; Soffiati, Giuliano; Fontanelli, Alessandro; Zanco, Pierluigi; Ronco, Claudio
• Other Names: Rosner Mitchell H. Academic Editor.
• Is Part Of: International journal of nephrology. Volume 2011(2011)
• Publication Date: 2010-09-30
• Subjects: Nephrology -- Periodicals; Nephrology; Kidney Diseases; Nephrology; Periodicals; Periodicals; Fulltext; Internet Resources; Electronic journals; 616.61
• DOI: 10.4061/2011/425923
• Languages: English
• ISSNs: 2090-214X

Abstract

Abstract : We examined association of inducible myocardial perfusion defects with cardiorenal biomarkers, and of diminished left ventricular ejection fraction (LVEF) with kidney injury marker plasma neutrophil gelatinase-associated lipocalin (NGAL). Patients undergoing nuclear myocardial perfusion stress imaging were divided into 2 groups. Biomarkers were analyzed pre- and poststress testing. Compared to the patients in the low ischemia group (n = 16 ), the patients in the high ischemia group (n = 18 ) demonstrated a significantly greater rise in cardiac biomarkers plasma BNP, NT-proBNP and cTnI. Subjects were also categorized based on pre- or poststress test detectable plasma NGAL. With stress, the group with no detectable NGAL had a segmental defect score 4.2 compared to 8.2 (P = .06 ) in the detectable NGAL group, and 0.9 vs. 3.8 (P = .03 ) at rest. BNP rose with stress to a greater degree in patients with detectable NGAL (10.2 vs. 3.5 pg/mL, P = .03 ). LVEF at rest and with stress was significantly lower in the detectable NGAL group; 55.8 versus 65.0 (P = .03 ) and 55.1 vs. 63.8 (P = .04 ), respectively. Myocardial perfusion defects associate with biomarkers of cardiac stress, and detectable plasma NGAL with significantly lower LVEF, suggesting a specific heart-kidney link.