Clinical Application of a Modular Genomics Technique in Systemic Lupus Erythematosus: Progress towards Precision Medicine. (30th August 2016)

• Record Type: Journal Article
• Authors: Zollars, Eric; Courtney, Sean M.; Wolf, Bethany J.; Allaire, Norm; Ranger, Ann; Hardiman, Gary; Petri, Michelle
• Other Names: Wigdahl Brian Academic Editor.
• Is Part Of: International journal of genomics. Volume 2016(2016)
• Publication Date: 2016-08-30
• Subjects: Genomes -- Periodicals; Genomics -- Periodicals; Cytogenetics -- Periodicals; Genomics; Genome; Molecular Biology; Cytogenetics; Genomes; Genomics; Periodicals; 572.86
• DOI: 10.1155/2016/7862962
• Languages: English
• ISSNs: 2314-436X

Abstract

Abstract : Monitoring disease activity in a complex, heterogeneous disease such as lupus is difficult. Both over- and undertreatment lead to damage. Current standard of care serologies are unreliable. Better measures of disease activity are necessary as we move into the era of precision medicine. We show here the use of a data-driven, modular approach to genomic biomarker development within lupus—specifically lupus nephritis.