Genetic Polymorphisms of Alcohol Dehydrogenase and Aldehyde Dehydrogenase: Alcohol Use and Type 2 Diabetes in Japanese Men. (8th June 2010)

• Record Type: Journal Article
• Authors: Yin, Guang; Ohnaka, Keizo; Morita, Makiko; Tabata, Shinji; Tajima, Osamu; Kono, Suminori
• Other Names: Panagiotakos Demosthenes Academic Editor.
• Is Part Of: Epidemiology research international. Volume 2011(2011)
• Publication Date: 2010-06-08
• Subjects: Epidemiology -- Periodicals; Epidemiology; Epidemiology; Epidemiology -- Periodicals; Periodical; Periodicals; 614.4
• DOI: 10.1155/2011/583682
• Languages: English
• ISSNs: 2090-2972

Abstract

Abstract : This study investigated the association of ADH1B (rs1229984) and ALDH2 (rs671) polymorphisms with glucose tolerance status, as determined by a 75-g oral glucose tolerance test, and effect modification of these polymorphisms on the association between alcohol consumption and glucose intolerance in male officials of the Self-Defense Forces. The study subjects included 1520 men with normal glucose tolerance, 553 with prediabetic condition (impaired fasting glucose and impaired glucose tolerance), and 235 men with type 2 diabetes. There was an evident interaction between alcohol consumption and ADH1B polymorphism in relation to type 2 diabetes (interactionP = .03 ). The ALDH2 4 ∗ 87 Lys allele was associated with a decreased prevalence odds of type 2 diabetes regardless of alcohol consumption. In conclusion, the ADH1B polymorphism modified the association between alcohol consumption and type 2 diabetes. A positive association between alcohol consumption and type 2 diabetes was confounded by ALDH2 polymorphism.