Multiscale modelling the effects of CI genetic evolution in mosquito population on the control of dengue fever. Issue 1 (December 2017)

• Record Type: Journal Article
• Authors: He, Sha; Zhang, Xianghong; Liang, Juhua; Tang, Sanyi
• Is Part Of: Scientific reports. Volume 7:Issue 1(2017)
• Page Start: 1
• Page End: 15
• Publication Date: 2017-12
• Subjects: Natural history -- Research -- Periodicals; Biology -- Research -- Periodicals; Physical sciences -- Research -- Periodicals; Earth sciences -- Research -- Periodicals; Environmental sciences -- Research -- Periodicals; 502.85
• DOI: 10.1038/s41598-017-13896-x
• Languages: English
• ISSNs: 2045-2322

Abstract

Abstract EndosymbioticWolbachia bacteria are widely applied for the control of dengue fever by manipulating the reproductive mechanism of mosquitoes, including maternal inheritance and cytoplasmic incompatibility (CI). CI means that the offsprings from the matings betweenWolbachia infected males and uninfected females can not be hatched. At present, CI effect is assumed as a constant in most of dynamic systems for the spread ofWolbachia . However, their spread may arouse the evolution of mosquitoes to resist CI. Thus, a multiscale model combining a birth-pulse model with a gene-induced discrete model for the frequencies of alleles is proposed to describe the spread ofWolbachia in mosquito population with resistance allele of CI. The main results indicate that the strategy of population eradication can not be realized, while the strategy of population replacement may be realized with the success of sensitive or resistance allele. If appropriateWolbachia strains can not be selected, then there is a high probability of the failure of population replacement. Moreover, Wolbachia -induced parameters may arouse the catastrophic shifts among stable states of the model. In addition, the demographic parameters andWolbachia -induced parameters may affect the level and the speed of population replacement and the density of uninfected mosquitoes.