Low‐cost LED‐based Photo‐CIDNP Enables Biocompatible Hyperpolarization of 19F for NMR and MRI at 7 T and 4.7 T. Issue 19 (13th July 2018)

• Record Type: Journal Article
• Authors: Bernarding, Johannes; Euchner, Frederike; Bruns, Christian; Ringleb, Rainer; Müller, Darius; Trantzschel, Thomas; Bargon, Joachim; Bommerich, Ute; Plaumann, Markus
• Is Part Of: Chemphyschem. Volume 19:Issue 19(2018)
• Page Start: 2453
• Page End: 2456
• Publication Date: 2018-07-13
• Subjects: fluorine -- 3-fluoro-DL-tyrosine -- hyperpolarization -- NMR spectroscopy -- photo-CIDNP; Chemistry, Physical and theoretical -- Periodicals; 541.05
• DOI: 10.1002/cphc.201800570
• Languages: English
• ISSNs: 1439-4235

Abstract

Abstract: Substrates containing 19 F can serve as background‐free reporter molecules for NMR and MRI. However, in vivo applications are still limited due to the lower signal‐to‐noise ratio (SNR) when compared with 1 H NMR. Although hyperpolarization can increase the SNR, to date, only photo‐chemically induced dynamic nuclear polarization (photo‐CIDNP) allows for hyperpolarization without harmful metal catalysts. Photo‐CIDNP was shown to significantly enhance 19 F NMR signals of 3‐fluoro‐DL‐tyrosine in aqueous solution using flavins as photosensitizers. However, lasers were used for photoexcitation, which is expensive and requires appropriate protection procedures in a medical or lab environment. Herein, we report 19 F MR hyperpolarization at 4.7 T and 7 T with a biocompatible system using a low‐cost and easy‐to‐handle LED‐based set‐up. First hyperpolarized 19 F MR images could be acquired, because photo‐CIDNP enabled repetitive hyperpolarization without adding new substrates. Abstract : Substrates containing 19 F can serve as background‐free reporter molecules for NMR and MRI. Hyperpolarization allows for a significant increase of SNR. photo‐CIDNP enhance 19 F NMR signals of 3‐fluoro‐DL‐tyrosine in aqueous solution. Here, we report 19 F MR hyperpolarization at 4.7 T and 7 T with a biocompatible system using a low‐cost and easy‐to‐handle LED‐based set‐up.