Are perioperative allogeneic blood transfusions associated with 90‐days infection after operative treatment for bone metastases?. Issue 8 (18th November 2016)

• Record Type: Journal Article
• Authors: Paulino Pereira, Nuno Rui; Langerhuizen, David W.G.; Janssen, Stein J.; Hornicek, Francis J.; Ferrone, Marco L.; Harris, Mitchel B.; Schwab, Joseph H.
• Is Part Of: Journal of surgical oncology. Volume 114:Issue 8(2016)
• Page Start: 997
• Page End: 1003
• Publication Date: 2016-11-18
• Subjects: neoplasm metastasis -- spine -- extremities -- blood transfusion -- surgery -- infection; Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.24440
• Languages: English
• ISSNs: 0022-4790

Abstract

Abstract : Background and Objectives: We assessed whether allogeneic blood transfusions were associated with infection—within 90 days—after surgery for bone metastatic disease. Furthermore, we assessed other risk factors associated with infection. Methods: We included 1, 266 patients surgically treated for a bone metastasis at two hospitals between 2002 and 2013. Blood transfusions within 7 days before and after surgery were considered perioperative. Results: We found no independent association between exposure to blood transfusion and infection (odds ratio [OR] 1.02, 95% confidence interval [CI]: 0.76–1.37, P = 0.889), nor a dose–response relationship (OR 1.02, 95%CI: 0.98–1.07, P = 0.245). Older age (OR 1.01, 95%CI: 1.00–1.02, P = 0.035), a higher modified Charlson comorbidity index (OR 1.13, 95%CI: 1.05–1.22, P = 0.002), surgery to the axial skeleton (OR 1.89, 95%CI: 1.42–2.51, P < 0.001), and previous radiotherapy (OR 1.45, 95%CI 1.07–1.96, P = 0.015) were independently associated with infection. Conclusions: There was no association between allogeneic blood transfusion and infection. We found other risk factors that should be taken into consideration when deciding to operate. J. Surg. Oncol. 2016;114:997–1003 . © 2016 Wiley Periodicals, Inc.