Cognitive impairment in Glucocerebrosidase (GBA)‐associated PD: Not primarily associated with cerebrospinal fluid Abeta and Tau profiles. Issue 12 (2nd November 2017)

• Record Type: Journal Article
• Authors: Lerche, Stefanie; Schulte, Claudia; Srulijes, Karin; Pilotto, Andrea; Rattay, Tim W.; Hauser, Ann‐Kathrin; Stransky, Elke; Deuschle, Christian; Csoti, Ilona; Lachmann, Ingolf; Zetterberg, Henrik; Liepelt‐Scarfone, Inga; Gasser, Thomas; Maetzler, Walter; Berg, Daniela; Brockmann, Kathrin
• Is Part Of: Movement disorders. Volume 32:Issue 12(2017)
• Page Start: 1780
• Page End: 1783
• Publication Date: 2017-11-02
• Subjects: Parkinson -- GBA -- Abeta -- Tau -- alpha‐synuclein -- CSF; Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.27199
• Languages: English
• ISSNs: 0885-3185

Abstract

ABSTRACT: Background: A proportion of idiopathic Parkinson's disease patients (PD idiopathic ) with dementia show altered CSF profiles of amyloid β (Aβ) and Tau. PD patients with Glucocerebrosidase ( GBA ) mutations (PD GBA ) present with even more cognitive decline than seen in PD idiopathic . Objective: The objective of this study was to evaluate whether CSF profiles of Aβ and tau are associated with the prominent cognitive impairment in PD GBA . Methods: CSF levels of Aβ1‐42, t‐Tau, p‐Tau, and total alpha‐synuclein were assessed in 479 participants (50 PD GBA, 308 PD idiopathic, 121 healthy controls). Results: Older age was associated with cognitive impairment in PD GBA and PD idiopathic . Despite prominent cognitive impairment, PD GBA showed similar CSF levels of Aβ1‐42, t‐Tau, and p‐Tau as seen in healthy controls. In contrast, lower levels of Aβ1‐42 and higher levels of t‐Tau and p‐Tau were associated with worse cognitive performance in PD idiopathic . Conclusions: The prominent cognitive impairment in PD GBA seems not primarily associated with Aβ and Tau profiles in CSF. © 2017 International Parkinson and Movement Disorder Society