Long-Term Endoscopic Follow-Up of Patients with Chronic Radiation Proctopathy after Brachytherapy for Prostate Cancer. (9th June 2016)

• Record Type: Journal Article
• Authors: Ohtani, Masahiro; Suto, Hiroyuki; Nosaka, Takuto; Saito, Yasushi; Ozaki, Yoshihiko; Hayama, Ryoko; Naito, Tatsushi; Takahashi, Kazuto; Ofuji, Kazuya; Matsuda, Hidetaka; Hiramatsu, Katsushi; Nemoto, Tomoyuki; Shioura, Hiroki; Kimura, Hirohiko; Aoki, Yoshitaka; Yokoyama, Osamu; Nakamoto, Yasunari
• Other Names: O'Dwyer Patrick J. Academic Editor.
• Is Part Of: Diagnostic and therapeutic endoscopy. Volume 2016(2016)
• Publication Date: 2016-06-09
• Subjects: Endoscopy -- Periodicals; Endoscopie; Endoscopy; Endoscopy -- Periodicals; Electronic journals; Periodicals; 616.07545
• DOI: 10.1155/2016/1414090
• Languages: English
• ISSNs: 1070-3608

Abstract

Abstract : Background . Chronic radiation proctopathy (CRP) is late toxicity and associated with morbidity. Aim . To investigate the predictors of prognosis in patients with CRP after brachytherapy (BT). Methods . One hundred four patients with prostate cancer were treated with BT or BT followed by external-beam radiotherapy (BT + EBRT). We retrospectively investigated the 5-year incidence of rectal bleeding and endoscopic findings of CRP using the Vienna Rectoscopy Score (VRS). Twenty patients with VRS ≥ 1 were divided into the improved VRS group without treatment, unchanged VRS group, and treated group. The parameters associated with alteration of VRS were analyzed. Results . The incidence of rectal bleeding was 24%. The risk of rectal bleeding was higher in patients treated with BT + EBRT compared to those treated with BT (p < 0.0 001 ). The incidence of superficial microulceration was higher in the improved VRS group than in the unchanged VRS group (p < 0.05 ). The incidence of multiple confluent telangiectasia or superficial ulcers > 1 cm 2 was higher in the treated group than in both the improved and unchanged VRS groups (p < 0.05 ). Conclusions . Patients treated with BT + EBRT have a high risk of CRP. Endoscopic findings were useful for prognostic prediction of CRP.