Potential Explanatory Factors for Higher Incident Hip Fracture Risk in Older Diabetic Adults. (7th August 2011)

• Record Type: Journal Article
• Authors: Strotmeyer, Elsa S.; Kamineni, Aruna; Cauley, Jane A.; Robbins, John A.; Fried, Linda F.; Siscovick, David S.; Harris, Tamara B.; Newman, Anne B.
• Other Names: Crilly Richard Academic Editor.
• Is Part Of: Current gerontology and geriatrics research. Volume 2011(2011)
• Publication Date: 2011-08-07
• Subjects: Gerontology -- Periodicals; Geriatrics -- Periodicals; Older people -- Physiology -- Periodicals; Older people -- Health and hygiene -- Periodicals; Older people -- Diseases -- Periodicals; 612.6705
• DOI: 10.1155/2011/979270
• Languages: English
• ISSNs: 1687-7063

Abstract

Abstract : Type 2 diabetes is associated with higher fracture risk. Diabetes-related conditions may account for this risk. Cardiovascular Health Study participants (N = 5641 ; 42.0% men; 15.5% black; 72.8± 5.6 years) were followed 10.9± 4.6 years. Diabetes was defined as hypoglycemic medication use or fasting glucose (FG)≥ 126 mg/dL. Peripheral artery disease (PAD) was defined as ankle-arm index <0.9. Incident hip fractures were from medical records. Crude hip fracture rates (/1000 person-years) were higher for diabetic vs. non-diabetic participants with BMI <25 (13.6, 95% CI: 8.9–20.2 versus 11.4, 95% CI: 10.1–12.9) and BMI≥ 25 to <30 (8.3, 95% CI: 5.7–11.9 versus 6.6, 95% CI: 5.6–7.7), but similar for BMI≥ 30. Adjusting for BMI, sex, race, and age, diabetes was related to fractures (HR = 1.34; 95% CI: 1.01–1.78). PAD (HR = 1.25 (95% CI: 0.92–1.57)) and longer walk time (HR = 1.07 (95% CI: 1.04–1.10)) modified the fracture risk in diabetes (HR = 1.17 (95% CI: 0.87–1.57)). Diabetes was associated with higher hip fracture risk after adjusting for BMI though this association was modified by diabetes-related conditions.