Multifunctional melanin-like nanoparticles for bone-targeted chemo-photothermal therapy of malignant bone tumors and osteolysis. (November 2018)

• Record Type: Journal Article
• Authors: Wang, Yitong; Huang, Quan; He, Xiao; Chen, Hui; Zou, Yuan; Li, Yiwen; Lin, Kaili; Cai, Xiaopan; Xiao, Jianru; Zhang, Qiang; Cheng, Yiyun
• Is Part Of: Biomaterials. Volume 183(2018)
• Page Start: 10
• Page End: 19
• Publication Date: 2018-11
• Subjects: Malignant bone tumor -- Melanin-like nanoparticles -- Bone-targeted delivery -- Magnetic resonance imaging -- Chemo-photothermal therapy; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2018.08.033
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: Malignant bone tumors associated with aggressive osteolysis are currently hard to be cured by the clinical strategies. Nevertheless, nanomedicine might provide a promising therapeutic opportunity. Here, we developed a multifunctional melanin-like nanoparticle for bone-targeted chemo-photothermal treatment of malignant bone tumors. The particle was originally fabricated from alendronate-conjugated polydopamine nanoparticle (PDA-ALN) that exhibited excellent photothermal effect and high affinity to hydroxyapatite. PDA/Fe-ALN significantly enhanced the magnetic resonance contrast of the bone tumors in vivo, suggesting that more PDA-ALN accumulated at the osteolytic bone lesions in the tumors compared with the non-targeting PDA. Chemodrug SN38 was efficiently loaded on PDA-ALN, and the drug release could be triggered by near-infrared irradiation and acidic stimulus. Finally, the combined chemo-photothermal therapy efficiently suppressed the growth of bone tumors and reduced the osteolytic damage of bones at a mild temperature around 43 °C. This study provides an efficient and robust nanotherapeutics for the treatment of malignant bone tumors.