Pyroxazone, a new neuroprotective compound from Streptomyces sp. RAN54. (November 2018)
- Record Type:
- Journal Article
- Title:
- Pyroxazone, a new neuroprotective compound from Streptomyces sp. RAN54. (November 2018)
- Main Title:
- Pyroxazone, a new neuroprotective compound from Streptomyces sp. RAN54
- Authors:
- Hayakawa, Yoichi
Kuriyama, Taishin
Ibusuki, Yuta
Kimata, Shoko - Abstract:
- Abstract A neuroprotective compound designated pyroxazone (1 ) was isolated from the culture broth ofStreptomyces sp. RAN54. The molecular formula of1 was established as C18 H14 N2 O5 by high-resolution FAB-MS. The structure was determined to be a new 2-amino-3H -phenoxazin-3-one derivative by NMR spectroscopic analysis. Pyroxazone (1 ) protected C6 rat glioma cells and N18-RE-105 rat primary retina-mouse neuroblastoma hybrid cells from glutamate-induced toxicity with EC50 s of 8.2 µM and 1.7 µM, respectively.
- Is Part Of:
- Journal of antibiotics. Volume 71:Number 11(2018:Nov.)
- Journal:
- Journal of antibiotics
- Issue:
- Volume 71:Number 11(2018:Nov.)
- Issue Display:
- Volume 71, Issue 11 (2018)
- Year:
- 2018
- Volume:
- 71
- Issue:
- 11
- Issue Sort Value:
- 2018-0071-0011-0000
- Page Start:
- 962
- Page End:
- 964
- Publication Date:
- 2018-11
- Subjects:
- Antibiotics -- Periodicals
615.329 - Journal URLs:
- https://www.nature.com/ja/ ↗
http://www.nature.com/ ↗ - DOI:
- 10.1038/s41429-018-0085-4 ↗
- Languages:
- English
- ISSNs:
- 0021-8820
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 4937.900000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 10808.xml