Equilibrium Analysis of a Yellow Fever Dynamical Model with Vaccination. (5th March 2015)

• Record Type: Journal Article
• Authors: Martorano Raimundo, Silvia; Amaku, Marcos; Massad, Eduardo
• Other Names: Liao Chung-Min Academic Editor.
• Is Part Of: Computational and mathematical methods in medicine. Volume 2015(2015)
• Publication Date: 2015-03-05
• Subjects: Medicine -- Computer simulation -- Periodicals; Medicine -- Mathematical models -- Periodicals; 610.11
• DOI: 10.1155/2015/482091
• Languages: English
• ISSNs: 1748-670X

Abstract

Abstract : We propose an equilibrium analysis of a dynamical model of yellow fever transmission in the presence of a vaccine. The model considers both human and vector populations. We found thresholds parameters that affect the development of the disease and the infectious status of the human population in the presence of a vaccine whose protection may wane over time. In particular, we derived a threshold vaccination rate, above which the disease would be eradicated from the human population. We show that if the mortality rate of the mosquitoes is greater than a given threshold, then the disease is naturally (without intervention) eradicated from the population. In contrast, if the mortality rate of the mosquitoes is less than that threshold, then the disease is eradicated from the populations only when the growing rate of humans is less than another threshold; otherwise, the disease is eradicated only if the reproduction number of the infection after vaccination is less than 1. When this reproduction number is greater than 1, the disease will be eradicated from the human population if the vaccination rate is greater than a given threshold; otherwise, the disease will establish itself among humans, reaching a stable endemic equilibrium. The analysis presented in this paper can be useful, both to the better understanding of the disease dynamics and also for the planning of vaccination strategies.