A new method using 1, 3, 5-triazine as an umpolung hydrogen cyanide equivalent toward the syntheses of isoquinolinone and 2-pyridone derivatives. Issue 43 (24th October 2018)

• Record Type: Journal Article
• Authors: Hayashida, Joji; Yoshida, Shinya
• Is Part Of: Tetrahedron letters. Volume 59:Issue 43(2018)
• Page Start: 3876
• Page End: 3879
• Publication Date: 2018-10-24
• Subjects: Triazine -- Cyclization -- Umpolung -- Isoquinolinone -- 2-Pyridone; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2018.09.029
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: An efficient and simple approach to access various isoquinolinone and 2-pyridones derivatives. A useful application of 1, 3, 5-trizaine as an umpolung hydrogen cyanide synthetic equivalent. A novel cyclization for the synthesis of amino-isoquinoline derivatives. Abstract: An investigation of Hermecz and Hartenstein's cyclization methods was conducted. Overcoming the limited substrate scope allowed the expansion of the synthetic application of 1, 3, 5-triazine as an umpolung hydrogen cyanide equivalent. The reaction proceeded under mild conditions to provide various isoquinolinone and 2-pyridone derivatives with excellent yields.