Reducing Haemorrhagic Transformation after Thrombolysis for Stroke: A Strategy Utilising Minocycline. (3rd April 2013)

• Record Type: Journal Article
• Authors: Blacker, David J.; Prentice, David; Alvaro, Anthony; Bates, Timothy R.; Bynevelt, Michael; Kelly, Andrew; Kho, Lay Kun; Kohler, Edith; Hankey, Graeme J.; Thompson, Andrew; Major, Taryn
• Other Names: Moonis Majaz Academic Editor.
• Is Part Of: Stroke research and treatment. Volume 2013(2013)
• Publication Date: 2013-04-03
• Subjects: Cerebrovascular disease -- Periodicals; Stroke; Cerebrovascular Disorders; Cerebrovascular disease; Periodicals; Periodicals; Fulltext; Internet Resources; Periodicals; 616.81
• DOI: 10.1155/2013/362961
• Languages: English
• ISSNs: 2090-8105

Abstract

Abstract : Haemorrhagic transformation (HT) of recently ischaemic brain is a feared complication of thrombolytic therapy that may be caused or compounded by ischaemia-induced activation of matrix metalloproteinases (MMPs). The tetracycline antibiotic minocycline inhibits matrix MMPs and reduces macroscopic HT in rodents with stroke treated with tissue plasminogen activator (tPA). The West Australian Intravenous Minocycline and TPA Stroke Study (WAIMATSS) aims to determine the safety and efficacy of adding minocycline to tPA in acute ischaemic stroke. The WAIMATSS is a multicentre, prospective, and randomised pilot study of intravenous minocycline, 200 mg 12 hourly for 5 doses, compared with standard care, in patients with ischaemic stroke treated with intravenous tPA. The primary endpoint is HT diagnosed by brain CT and MRI. Secondary endpoints include clinical outcome measures. Some illustrative cases from the early recruitment phase of this study will be presented, and future perspectives will be discussed.