Feeding of tobacco blend or nicotine induced weight loss associated with decreased adipocyte size and increased physical activity in male mice. (March 2018)

• Record Type: Journal Article
• Authors: Liu, Mingxia; Chuang Key, Chia-Chi; Weckerle, Allison; Boudyguina, Elena; Sawyer, Janet K.; Gebre, Abraham K.; Spoo, Wayne; Makwana, Om; Parks, John S.
• Is Part Of: Food and chemical toxicology. Volume 113(2018)
• Page Start: 287
• Page End: 295
• Publication Date: 2018-03
• Subjects: Adipose triglyceride mobilization -- Food consumption -- Insulin sensitivity -- Glucose disposal; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2018.01.058
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: Although epidemiological data and results from rodent studies support an inverse relationship between nicotine consumption and body weight, the molecular mechanisms are poorly understood. CD-1 mice were fed a basal diet or a basal diet containing low or high dose smokeless tobacco blend or high dose nicotine tartrate for 14 weeks. High dose tobacco blend and nicotine tartrate diets vs. basal diet reduced mouse body weight (16.3% and 19.7%, respectively), epididymal (67.6% and 72.5%, respectively) and brown adipose weight (42% and 38%, respectively), epididymal adipocyte size (46.4% and 41.4%, respectively), and brown adipose tissue lipid droplet abundance, with no elevation of adipose tissue inflammation. High dose tobacco blend and nicotine diets also increased mouse physical activity and decreased respiratory exchange ratio, suggesting that high dose nicotine intake induces adipose tissue triglyceride lipolysis to provide fatty acids as an energy source. Both low and high dose tobacco blend and nicotine diet feeding vs. basal diet increased plasma insulin levels (2.9, 3.6 and 4.3-fold, respectively) and improved blood glucose disposal without affecting insulin sensitivity. Feeding of the high dose tobacco blend or nicotine feeding in mice induces body weight loss likely by increasing physical activity and stimulating adipose tissue triglyceride lipolysis. Highlights: High dose tobacco blend and nicotine diets reduce body weight and fat mass in mice. High dose tobacco blend and nicotine diets increase physical activity in mice. High dose dietary nicotine induces mouse adipose tissue triglyceride lipolysis. High dose tobacco blend and nicotine diets increase plasma insulin levels in mice. High dose tobacco blend and nicotine diets improve blood glucose disposal in mice.