Boron nitride nanotube-based amphiphilic hybrid nanomaterials for superior encapsulation of hydrophobic cargos. (December 2017)

• Record Type: Journal Article
• Authors: Abu Saleh, Doaa; Niskanen, Jukka; Xue, Yanming; Golberg, Dmitri; Winnik, Françoise M.; Sosnik, Alejandro
• Is Part Of: Materials today chemistry. Volume 6(2017)
• Page Start: 45
• Page End: 50
• Publication Date: 2017-12
• Subjects: Core-shell amphiphilic hybrid nanomaterials -- Boron nitride nanotubes -- Polymeric micelles -- Drug encapsulation -- Curcumin; Chemistry -- Periodicals; Materials -- Research -- Periodicals; Materials science -- Periodicals; Chemistry; Materials -- Research; Electronic journals; Periodicals; 660.282
• DOI: 10.1016/j.mtchem.2017.09.003
• Languages: English
• ISSNs: 2468-5194

Abstract

Abstract: We report an organic-inorganic hybrid core-shell nanomaterial obtained by conjugation of an amphiphilic monomethoxy-poly(ethylene glycol)- b -poly(epsilon-caprolactone) diblock copolymer to hydroxylated boron nitride nanotubes (BNNTs). The extent of copolymer grafting reached 64% w/w, an exceptionally high value. The hybrid materials exhibit excellent physical stability in water and an outstanding loading capacity (31.3% w/w) for curcumin, a hydrophobic drug. Moreover, they present good compatibility with the Caco2 cell line, a model of intestinal epithelium. Our findings demonstrate the potential of multifunctional hybrid BNNTs to serve as a platform for complex amphiphilic nanoparticle architectures with improved features. Graphical abstract: Highlights: Organic–inorganic core-shell nanomaterials were produced by conjugation of a polymeric amphiphile to boron nitride nanotubes. The extent of copolymer grafting reached 64% w/w, an exceptionally high value. The hybrid nanomaterial exhibits outstanding loading capacity (31.3% w/w) for curcumin. The hybrid nanomaterial presents good compatibility with the Caco2 cell line.