Direct Synthesis of a Covalently Self‐Assembled Peptide Nanogel from a Tyrosine‐Rich Peptide Monomer and Its Biomineralized Hybrids. Issue 20 (23rd April 2018)

• Record Type: Journal Article
• Authors: Min, Kyoung‐Ik; Kim, Dong‐Hwi; Lee, Hyune‐Jea; Lin, Liwei; Kim, Dong‐Pyo
• Is Part Of: Angewandte Chemie international edition. Volume 57:Issue 20(2018)
• Page Start: 5630
• Page End: 5634
• Publication Date: 2018-04-23
• Subjects: covalent self-assembly -- metal–peptide hybrids -- nanogels -- peptides -- tyrosine; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201713261
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: There has been significant progress in the self‐assembly of biological materials, but the one‐step covalent peptide self‐assembly for well‐defined nanostructures is still in its infancy. Inspired by the biological functions of tyrosine, a covalently assembled fluorescent peptide nanogel is developed by a ruthenium‐mediated, one‐step photo‐crosslinking of tyrosine‐rich short peptides under the visible light within 6 minutes. The covalently assembled peptide nanogel is stable in various organic solvents and different pH levels, unlike those made from vulnerable non‐covalent assemblies. The semipermeable peptide nanogel with a high density of redox‐active tyrosine acts as a novel nano‐bioreactor, allowing the formation of uniform metal–peptide hybrids by selective biomineralization under UV irradiation. As such, this peptide nanogel could be useful in the design of novel nanohybrids and peptidosomes possessing functional nanomaterials. Abstract : Peptide nanogels inspired by natural living systems are formed by one‐step covalent self‐assembly. The covalently assembled fluorescent peptide nanogel shows superior chemical stability in various organic solvents and at different pH, unlike vulnerable non‐covalent assemblies. It serves as a unique nano‐bioreactor for preparing uniform metal–peptide hybrids by a green synthetic approach.