Primary Amyloidosis Manifesting as Cholestatic Jaundice after Laparoscopic Cholecystectomy. (7th June 2015)

• Record Type: Journal Article
• Authors: Misiakos, Evangelos P.; Bagias, George; Tiniakos, Dina; Roditis, Konstantinos; Zavras, Nick; Papanikolaou, Ioannis; Tsirigotis, Panagiotis; Liakakos, Theodore; Machairas, Anastasios
• Other Names: Santori Gregorio Academic Editor.
• Is Part Of: Case reports in surgery. Volume 2015(2015)
• Publication Date: 2015-06-07
• Subjects: Surgery -- Periodicals; Surgery -- Case studies -- Periodicals; Surgical Procedures, Operative; General Surgery; Surgery; Electronic journals; Periodicals; Case studies; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 617
• DOI: 10.1155/2015/353818
• Languages: English
• ISSNs: 2090-6900

Abstract

Abstract : A 71-year-old female patient with cholelithiasis who had undergone laparoscopic cholecystectomy was admitted with obstructive jaundice (total bilirubin ~6 mg/dL) three months later. An ERCP was performed, in which a gallstone was found, followed by a sphincterotomy and cleansing of the bile duct. Due to deterioration of jaundice (>25 mg/dL), a new, unsuccessful ERCP and stent placement was carried out. Because of ongoing cardiac failure, she underwent an echocardiogram which revealed restrictive cardiomyopathy possibly due to amyloidosis. A liver biopsy was performed, which was positive for amyloid deposits in the liver, and the diagnosis was confirmed by the detection of monoclonal λ IgG protein in urine. The patient's jaundice gradually deteriorated and she died one week later from hepatic insufficiency.