Photo‐biocatalytic One‐Pot Cascades for the Enantioselective Synthesis of 1, 3‐Mercaptoalkanol Volatile Sulfur Compounds. (14th April 2018)

• Record Type: Journal Article
• Authors: Lauder, Kate; Toscani, Anita; Qi, Yuyin; Lim, Jesmine; Charnock, Simon J.; Korah, Krupa; Castagnolo, Daniele
• Is Part Of: Angewandte Chemie. Volume 130:Number 20(2018)
• Page Start: 5905
• Page End: 5909
• Publication Date: 2018-04-14
• Subjects: Biokatalyse -- Flüchtige Schwefelverbindungen -- Ketoreduktasen -- Mercaptoalkanole -- Photokatalyse; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201802135
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: The synthesis of enantiomerically pure 1, 3‐mercaptoalkanol volatile sulfur compounds through a one‐pot photo‐biocatalytic cascade reaction is described. Two new KRED biocatalysts with opposite enantioselectivity were discovered and proved to be efficient on a wide range of substrates. The one‐pot cascade reaction combining photocatalytic thio‐Michael addition with biocatalytic ketoreduction in an aqueous medium provides a green and sustainable approach to enantiomerically pure 1, 3‐mercaptoalkanols in high yields with excellent enantioselectivity.