Role of autophagy in oocytogenesis, embryogenesis, implantation, and pathophysiology of pre‐eclampsia. Issue 4 (18th April 2017)

• Record Type: Journal Article
• Authors: Nakashima, Akitoshi; Aoki, Aiko; Kusabiraki, Tae; Shima, Tomoko; Yoshino, Osamu; Cheng, Shi‐Bin; Sharma, Surendra; Saito, Shigeru
• Is Part Of: Journal of obstetrics and gynaecology research. Volume 43:Issue 4(2017)
• Page Start: 633
• Page End: 643
• Publication Date: 2017-04-18
• Subjects: autophagy -- extravillous trophoblast -- hypoxia -- invasion -- pre‐eclampsia -- soluble endoglin; Gynecology -- Periodicals; Obstetrics -- Periodicals; 618.1005
• DOI: 10.1111/jog.13292
• Languages: English
• ISSNs: 1341-8076

Abstract

Abstract: Autophagy is a well‐conserved mechanism in cells from yeast to mammals, andautophagy maintains homeostasis against stress. The role of autophagy was originally shown to be a mechanism of energy production under starvation. In fact, multiple lines of evidence reveal that autophagy has numerous functions, such as protection from stress, energy regulation, immune regulation, differentiation, proliferation, and cell death. In the field of reproduction, the role of autophagy in implantation, embryogenesis, placentation, and delivery has become clearer. In addition, recent study has elucidated that the placenta has the ability to protect extraplacental cells from virus infection by activating autophagy. During resent research into autophagy, several issues have occurred in the interpretation of the autophagy status. In this review, we discuss the relation between autophagy and reproductive events, and show the importance of autophagy for placentation and pre‐eclampsia.